J Korean Orthop Assoc.
2002 Feb;37(1):31-35.
Thrombotic and Fibrinolytic Abnormality in Nontraumatic Osteonecrosis of the Femoral Head
- Affiliations
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- 1Department of Orthopaedic Surgery, Gyeong-Sang National University School of Medicine, Chinju, Korea. khkoo@nongae.gsnu.ac.kr
- 2Department of Preventive Medicine, Gyeong-Sang National University School of Medicine, Chinju, Korea.
- 3Department of Orthopaedic Surgery, Cheju National University School of Medicine, Cheju, Korea.
Abstract
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PURPOSE: This study was performed to determine whether abnormalities of thrombosis and fibrinolysis are associated with nontraumatic osteonecrosis of the femoral head.
MATERIALS AND METHODS
A case-control study was conducted in 24 patients with nontraumatic osteonecrosis of the femoral head. These patients were matched with 24 controls for gender, age (1-year range), and time of presentation (1-year range). The study included 19 men and 5 women, and the mean age of patients and controls was 46 years (range, 16-68 years). Eight patients had idiopathic osteonecrosis and the remaining 16 patients had secondary osteonecrosis. Protein C activity, protein C antigenicity, protein S activity, protein S antigenicity, antithrombin III, anticardiolipin antibody-Ig G, anticardiolipin antibody-Ig M, lupus anticoagulant, plasminogen, tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and lipoprotein(a) were investigated.
RESULTS
Protein C antigenecity and protein S antigenecity, which have been known to decrease in osteonecrosis patients, were increased in patients compared with those of controls (P<0.05). No significant differences were found in the levels of other thrombotic or fibrinolytic factors. In a subgroup of 16 patients with secondary osteonecrosis, the level of anticardiolipin antibody immunoglobulin M was greater than in the respective controls (P<0.05).
CONCLUSION
The results of the current study suggest that abnormalities in the coagulation and fibrinolytic system are not associated with the pathogenesis of osteonecrosis of the femoral head.