J Korean Orthop Res Soc.
2010 Jun;13(1):43-51.
Role of Mesenchymal Stem Cells in Patients with Nontraumatic Osteonecrosis of the Femoral Head
- Affiliations
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- 1Department of Orthopedic Surgery, Pusan National University School of Medicine, Busan, Korea. nari1006@hanmail.net
- 2Department of Education, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea.
Abstract
- Mesenchymal stem cells are stem cells originated from the mesoderm have the capacity to differentiate into cells of connective tissue lineages, including bone, fat, cartilage and muscle. Nontraumatic osteonecrosis of the femoral head has been suggested the cause is likely relevant to the poor proliferation activity of mesenchymal stem cells in the femoral head region. The altered function of mesenchymal stem cells may be responsible for the pathogenesis and progression of osteonecrosis, in steroid or alcohol induced nontraumatic osteonecrosis of femoral head.
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