J Korean Orthop Res Soc.
2003 Oct;6(2):265-273.
Healing of Injury of Meniscus Using Fibrin Glue and Meniscal Cell in Rabbit Model
- Affiliations
-
- 1Department of Chemical Engineering, Hanyang University, Seoul, Korea.
- 2School of Chemical Engineering, Seoul National University, Seoul, Korea.
- 3Department of Orthopaedic Surgery, Ansan Hospital, Korea University, Korea. canall@korea.ac.kr
Abstract
- PURPOSE
We attempt to heal the defect of meniscus using fibrin glue and allogenic meniscal cells in rabbit.
MATERIALS AND METHODS
Meniscal cells were isolated from medial meniscus of knee joint of rabbit and cultured and expanded in vitro. The mixture of fibrin glue and meniscal cells implanted to the defect of rabbit meniscus. Examination of gross morphology, histological and immunohistochemical staining of retrieved specimens were performed at 3 and 6 weeks.
RESULTS
Cultured cells uniformly displayed an elongated, fibroblastic and fibrocartilagenous morphology. The histological and immunohistochemical analysis revealed regeneration of meniscal tissue at the defect site.
CONCLUSION
Meniscal cell transplantation with fibrin glue resulted in the regeneration of meniscus tissue successfully in rabbit model. This approach could be applied for treatment of meniscus injury.
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