J Korean Pain Soc.  2004 Jun;17(1):19-23. 10.3344/jkps.2004.17.1.19.

Effect of Intravenous Adenosine Infusion on Temporal Intraoperative Blood Pressure Changes and Postoperative Pain Scores in Laparoscopic Cholecystectomy Patients

• Kim SS
• Seong KW
• Park HJ
• Lim JB
• Kim HK
• Kim YK
• Lee C

• KMID: 2104820
• DOI: http://doi.org/10.3344/jkps.2004.17.1.19

Abstract

BACKGROUND
Adenosine has been shown to exert an antinociceptive effect under experimental conditions in animals and humans. This study was performed to evaluate the effects of adenosine on postoperative pain and intraoperative blood pressure changes. METHODS: We studied 30 patients, aged <65 years, who underwent laparoscopic cholecystectomy under N2O-O2-isoflurane general anesthesia. Patients were randomized into two groups: an adenosine group (adenosine was infused continuously at 100-150 microgram/kg/min, n = 15) and a control group (normal saline infused at 4 ml/min, n = 15). Mean arterial blood pressure during the intraoperative period, and pain score at 30 minutes, 6 hours, 24 hours, and 48 hours after operation were checked. On patient request, meperidine was administrated intravenously. RESULTS: Pain scores and the cumulative doses of meperidine were much lower in the adenosine group than in the control group. The elevation of mean arterial pressure during pnemoperiton-eum was significantly attenuated in the adenosine group. CONCLUSIONS: This data suggests that intravenous adenosine infusion is effective at post-operative pain control following a laparoscopic cholecystectomy and that it is also effective at attenuating blood pressure elevation during pneumoperitoneum.

Keyword

adenosine, blood pressure; laparoscopic cholecystectomy; postoperative pain

MeSH Terms

Adenosine*
Anesthesia, General
Animals
Arterial Pressure
Blood Pressure*
Cholecystectomy, Laparoscopic*
Humans
Intraoperative Period
Meperidine
Pain, Postoperative*
Pneumoperitoneum
Adenosine
Meperidine