Korean J Anesthesiol.  2009 Aug;57(2):161-164. 10.4097/kjae.2009.57.2.161.

The effect of intraoperative remifentanil infusion on analgesic requirements after laparoscopic cholecystectomy

• Lee JJ
• Hong SJ
• Kim JS
• Hwang SM
• Lim SY
• Lee SK

• KMID: 2238083
• DOI: http://doi.org/10.4097/kjae.2009.57.2.161

Abstract

BACKGROUND
This study was designed to evaluate the effect of intraoperative remifentanil infusion on postoperative analgesics requirements after laparoscopic cholecystectomy. METHODS: One hundred adult patients scheduled for elective laparoscopic cholecystectomy were enrolled. Patients were randomly allocated to 2 groups to receive sevoflurane with remifentanil infusion (Group R) or not (group C). Sevoflurane concentration and remifentanil dose were adjusted to maintain BIS 40-60 and blood pressure within 20% of the preoperative value, respectively. We assessed the pain intensity by using the four-point verbal rating scale (VRS) (0 = no pain. 1 = slight pain, 2 = moderate pain, 3 = intense or severe pain) at 15 min intervals for 1 hour in recovery room and then at 3-h intervals for 24 h in surgical ward. The analgesic medication was given when VRS score was > or =2 or patients requested it. RESULTS: There were no differences between the two groups with respect to the requirements for postoperative analgesics in recovery room and surgical ward. CONCLUSIONS: Continuous remifentanil infusion (0.09 +/- 0.05 ug/kg/min) during laparoscopic cholecystectomy does not cause hyperalgesia and more analgesic requirements.

Keyword

Laparoscopic cholecystectomy; Pain; Remifentanil

MeSH Terms

Adult
Analgesics
Blood Pressure
Cholecystectomy, Laparoscopic
Humans
Hyperalgesia
Methyl Ethers
Piperidines
Recovery Room
Analgesics
Methyl Ethers
Piperidines