J Korean Pain Soc.  1995 Apr;8(1):43-50.

Comparative Effects on Postoperative Analgesia According to the Intravenous Dosage of Ketorolac

• Yoon MH
• Yoo KY
• Chung SS
• Jeong CY
• Im WM
• Park CJ
• Lee JH

Abstract

The purpose of this study was to compare postoperative analgesic effect according to intravenous doses of ketorolac. The ninety-eight adult patients, scheduled for elective surgery under general anesthesia, were randomly assigned to receive saline or one of the five doses of ketorolac (10, l5, 30, 45, 60 mg). After recoverg from anesthesia, saline or ketorolac was injected intravenously, and the visual analogue score, sedation secore, mean blood pressure, heart rate, and the incidence of nausea and vomiting were measured 30 minutes, 1 hour and 2 hours after the injection. Saline or 10 mg of ketorolac had no postanalgesic effect. Above l5mg of ketorolac had analgesic effect, but this analgesic effect was not increased with increasing doses of ketorolac (30, 4S, 60mg). Any side effects (nausea, vomiting, excessive sedation, cardiopulmonary depression, and renal and hematologic adverse events) was not observed associated with ketorolac administration. Those results suggested that 15mg of ketorolac is the most reliable dose for postoperative anlgesia in intravenous administration.

Keyword

Ketorolac; Intravenous dosage; Analgesia

MeSH Terms

Administration, Intravenous
Adult
Analgesia*
Anesthesia
Anesthesia, General
Blood Pressure
Depression
Heart Rate
Humans
Incidence
Ketorolac*
Nausea
Vomiting
Ketorolac