J Korean Radiol Soc.  1994 Mar;30(3):471-479.

Intra-arterial Cisplatin Chemotherapy in Uterine Cervix Cancer after Selective Internal lilac Arteriography

• Kim J
• Noh HT

Abstract

PURPOSE
Colposcopic response of preoperative uterine cervix carcinomas to intra-arterial cisplatin infusion chemotherapy was analyzed to evaluate the efficacy of this therapy after selective pelvic arteriography.
MATERIALS AND METHODS
Nine patients of stage 1/11 cervical carcinomas were treated twice with intra-arterial cisplatin chemotherapy of a 3-week interval, with every week follow-up of colposcopy and histology until the radical hysterectomy and pelvic lymphadenectomy on the 6th week. Cisplatin of 50mg/m~ was slowly infused via autoinjector for 10 minutes with the catheter tip placed in both internal iliac arteries around uterine artery branching.
RESULTS
Colposcopic regression rate of tumor size was as follows:more than 2/3 decrease of original size in 2 patients, 2/3-1/2 in 2 patients, less than 1/2 in 4 patients, but in one patient minimal increase in tumor size was recognized. Colposcopic and postoperative microscopic pathology revealed degeneration and necrosis of the tumor cells and/or adjacent lymph nodes and fibrosis of surrounding tissues. All patients have been doing well until postoperative 25 months without recurrence or significant complications.
CONCLUSION
Preoperative intra-arterial cisplatin chemotherapy after selective internal iliac rteriography is helpful to decrease tumor size and improve histologic response and prognosis in stage I and II cervical carcinomas.

MeSH Terms

Angiography*
Catheters
Cervix Uteri*
Cisplatin*
Colposcopy
Drug Therapy*
Female
Fibrosis
Follow-Up Studies
Humans
Hysterectomy
Iliac Artery
Lymph Node Excision
Lymph Nodes
Necrosis
Pathology
Prognosis
Recurrence
Uterine Artery
Cisplatin