J Korean Radiol Soc.  1994 Jun;30(6):1135-1140.

The Role of Endorectal Ultrasonography in the Follow-up Evaluation of the Uterine Cervical Carcinomas in Intra-arterial Cisplatin Chemotherapy

• Kim JC
• Ahn YJ

Abstract

PURPOSE
lntra-arterial cisplatin infusion chemotherapy delivers higher concentration of this therapeutic agent to the limited area of cervical carcinoma. We evaluated the role of endorectal ultrasonography (ERUS) in the analysis of the tumor response to this chemotherapy.
MATERIALS AND METHODS
ERUS was done in 20 patients of cervical carcinomas limited to the pelvis by rotating the 5 UHz linear arraytransducer along the reference sagittal plane in the middle of uterine cervix and vagina. We examined and compared the change of tumor size and morphology on ER US, before, during and after intra-arterial cisplatin (50 mg/m2) chemotherapy through internal lilac artery near uterine arterial branching. Colposcopy and radical hysterectomy with pelvic lymphadenectomy were performed in all patients, and ERUS findingswere compared with those findings.
RESULTS
ERUS correlated well with surgery in the estimation of preoperative tumor size and morphology. Tumor reduction rate on ERUS (100-the largest area of the preoperative tumor/the largest area of the initial tumor) was as follows: more than 75% decrease of the original size in 3 patients, 75% -50% in 6 patients, 50%-25% in 8 patients, and less than 25% in 3 patients. Hyperechoic reflecting areas were noted in 4 patients, which corresponded to gaseous necrosis on postoperative pathology.
CONCLUSION
ERUS is helpful to evaluate the morphologic change of cervical carcinoma limited tothe pelvis in intra-arterial cisplatin chemotherapy.

MeSH Terms

Arteries
Cervix Uteri
Cisplatin*
Colposcopy
Drug Therapy*
Female
Follow-Up Studies*
Humans
Hysterectomy
Lymph Node Excision
Necrosis
Pathology
Pelvis
Ultrasonography*
Vagina
Cisplatin