J Korean Soc Emerg Med.
2014 Dec;25(6):771-774. 10.0000/jksem.2014.25.6.771.
The Experience and Management of Two Cases of Metformin-associated Lactic Acidosis
- Affiliations
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- 1Division of Nephrology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea. kwangpmc@daum.net
- KMID: 2101256
- DOI: http://doi.org/10.0000/jksem.2014.25.6.771
Abstract
- Metformin, a dimethylbiguanide, is an oral antihyperglycemic drug used in treatment of type 2 diabetes mellitus. It has been reported that metformin may be associated with lactic acidosis in patients with clinical conditions such as renal failure and heart failure. Metformin-associated lactic acidosis (MALA) is a rare, but serious complication with a mortality rate of approximately 30~50%. Therefore, an aggressive treatment strategy including hemodialysis is recommended for these patients. Although continuous renal replacement therapy (CRRT) has been administered in hemodynamically unstable patients with MALA, there are few case reports describing the use of CRRT as a therapeutic modality in Korea. Here, we describe the case histories of two MALA patients who underwent treatment with CRRT.
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