J Korean Soc Pediatr Nephrol.  2006 Oct;10(2):238-243.

A Case of Extensive Cerebral Venous Thrombosis in Childhood Nephrotic Syndrome

• Son CH
• Lee EH
• Lee JH
• Park YS

Abstract

Nephrotic syndrome in childhood is known to be associated with a hypercoagulable state and thromboembolic complications, among which cerebral venous thrombosis is a very rare and serious one, with only a few isolated reports in the literature. A 9-year-old boy with known nephrotic syndrome was admitted due to a relapse with massive proteinuria and generalized edema. He complained of a prolonged frontal headache. The enhanced brain magnetic resonance imaging(MRI) showed a high signal in the region of the superior sagittal sinus and right transverse sinus consistent with a thrombus. He was managed with steroids, cyclosporine and warfarin. His headache subsided 2 weeks later and proteinuria resolved 1 month later. An MRI 2 months later was normal. We describe this case and review the literature to emphasize the importance of recognizing this potentially life threatening complication and initiating anticoagulation therapy.

Keyword

Cerebral venous thrombosis; Nephrotic syndrome; Childhood

MeSH Terms

Brain
Child
Cyclosporine
Edema
Headache
Humans
Magnetic Resonance Imaging
Male
Nephrotic Syndrome*
Proteinuria
Recurrence
Steroids
Superior Sagittal Sinus
Thrombosis
Venous Thrombosis*
Warfarin
Cyclosporine
Steroids
Warfarin