Korean Circ J.  2005 Jan;35(1):49-54. 10.4070/kcj.2005.35.1.49.

The Relationship between Microalbuminuria and Coronary Artery Stenosis or Inflammatory Markers in Patients with Angina Pectoris

• Kang DG
• Jeong MH
• Lim SY
• Yun KH
• Kim KH
• Lee SH
• Lee YS
• Hong YJ
• Park HW
• Kim JH
• Ahn YK
• Kim NH
• Cho JG
• Suh SP
• Park JC
• Kang JC

• KMID: 2093912
• DOI: http://doi.org/10.4070/kcj.2005.35.1.49

Abstract

BACKGROUND AND OBJECTIVES
Microalbuminuria is associated with increased cardiovascular risk factors and mortality. The aims of this study were to clarify the relationship between the spot urine albumin-creatinine ratio (ACR) and coronary artery stenosis on diagnostic coronary angiograms and to investigate its association with inflammatory markers.
SUBJECTS AND METHODS
One hundred thirteen consecutive patients, who underwent a diagnostic coronary angiogram, between April 2004 and July 2004, were divided into two groups: group I (n=89, 58+/-1 2 years, 6 1 male, no microalbuminuria) and group II (n=24, 65+/-10 years, 14 male, microalbuminuria). Microalbuminuria was diagnosed when the ACR was between 30 and 300 mg/g.cr.
RESULTS
The mean age was higher in group II than group I (58+/-1 2 vs. 65+/-1 0 years, p=0.013), and group II also showed higher levels of white blood cell (7.0+/-2.4 vs. 9.5+/-4.1 x 103/mm3, p=0.009), monocyte (0.4+/-0.2 vs. 0.5+/-0.2 x 103/mm3, p=0.039), homocysteine (8.8+/-3.5 vs. 10.8+/-4.1 micro mol/L, p=0.02) and fasting plasma glucose (126.1+/-33.6 vs. 183.7+/-75.3mg/dL, p=0.001), and more frequent higher value of high sensitivity C-reactive protein (>0.5mg/dL) (16.9 vs. 66.7%, p<0.001 ) compared with those of group I. There was a correlation between the ACR and all the inflammatory markers tested. Significant coronary lesions, requiring percutaneous coronary intervention, were more frequently detected in group II than in group I (50.6 vs. 75%, p=0.032).
CONCLUSION
The ACR was associated with significant coronary artery disease and the inflammatory markers.

Keyword

Albuminuria; Inflammation; Coronary disease

MeSH Terms

Albuminuria
Angina Pectoris*
Blood Glucose
C-Reactive Protein
Coronary Artery Disease
Coronary Disease
Coronary Stenosis*
Coronary Vessels*
Fasting
Homocysteine
Humans
Inflammation
Leukocytes
Male
Monocytes
Mortality
Percutaneous Coronary Intervention
Risk Factors
C-Reactive Protein
Homocysteine