Korean Circ J.  2000 Sep;30(9):1133-1138. 10.4070/kcj.2000.30.9.1133.

Heart Rate Variability in Inappropriate Sinus

• Lee CS
• Bae WH
• Lee HG
• Kim SH
• Ha JK
• Kim SH
• Ahn BJ
• Chun KJ
• Hong TJ
• Shin YW

• KMID: 2093756
• DOI: http://doi.org/10.4070/kcj.2000.30.9.1133

Abstract

BACKGROUND: Inappropriate sinus tachycardia(IST) manifests chronic nonparoxysmal sinus tachycardia in healthy individuals and is characterized by consistently elevated heart rate and exaggerated responses to minimal physical activity. Heart rate variability(HRV) using 24-hour Holter monitoring represents one of the methods of evaluating the harmony of autonomic nervous system activity. So, authors investigate the autonomic nervous system activity by the HRV in patients with IST.
METHODS
We compared the pattern of cardiac sympathetic and parasympathetic activity through the time domain analysis of heart rate variability with 24-hour Holter monitoring between 23 patients with IST and 23 healthy control subjects. None of the patients had organic heart disease as determined by routine laboratory examination and echocardiography. And then, time domain measures(mean NN, SDNN, SDANN, SD, rMSSD, pNN50) were analyzed.
RESULTS
The mean age of patients and control were 38+/-10 and 37 9 years, respectively(p=S). The mean clinical heart rate of patients and control was 104 5/min and 72+/-5/min, respectively(p<0.05). Among the time domain indices, mean of all normal RR intervals(mean NN), standard deviation of all normal RR intervals(SDNN), standard deviation of mean RR interval(SDANN), mean of standard deviations of all normal RR intervals(SD), root mean square successive differences between adjacent normal RR intervals(rMSSD), and percent of difference between adjacent normal RR intervals(pNN50) in the patient group were significantly shorter compared to control group(p<0.01).
CONCLUSION
In IST, cardiac vagal influence on the heart rate is blunted.

MeSH Terms

Autonomic Nervous System
Echocardiography
Electrocardiography, Ambulatory
Heart Diseases
Heart Rate*
Heart*
Humans
Motor Activity
Tachycardia, Sinus