Korean J Anat.
2003 Oct;36(5):427-433.
In vivo Study on the Japanese Encephalitis: Viral Localization and Histopathology in the Mouse Brain
- Affiliations
-
- 1Department of Virology, National Institute of Health, 5 Nokbun-dong, Eunpyung-gu, Seoul 122-701, Korea. ibkimmd@catholic.ac.kr
- 2Department of Anatomy, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul 137-701, Korea.
- 3National Genome Research Institute, National Institute of Health, 5 Nokbun-dong, Eunpyung-gu, Seoul 122-701, Korea.
Abstract
- Japanese encephalitis is a potentially lethal disease of the central nervous system caused by infection with Japanese encephalitis virus (JEV). JEV is the most common cause of encephalitis over a large part of eastern Asia. To establish and characterize in vivo model to study the Japanese encephalitis, the immunohistochemical localization of JEV and the histopathological finding were investigated in the brains of young adult mice infected with JEV by intraperitoneal inoculation. JEV was localized to neurons in discrete regions of the brain. Histopathological finding showed typical pattern of acute viral encephalitis, such as inflammatory cell infiltration in brain parenchyme and perivascular cuffs of mononuclear cells. These results suggest that this in vivo system can be used to study the mechanism of virus entry into the brain, cell specific tropism, and pathophysiology in Japanese encephalitis.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Japanese Encephalitis Associated with Flaccid Quadriplegia
- Japanese Encephalitis in Korea, 2010: Case Reports and Epidemiology
- Intracellular Localization of the Japanese Encephalitis Virus Capsid Protein
- The Japanese Encephalitis Vaccine: Worldwide and Korean Status
- Apoptotic Neuronal Death in the Mouse Brain Induced by Experimental Japanese Encephalitis Virus Infection
