Korean J Anesthesiol.  2011 Jul;61(1):35-41. 10.4097/kjae.2011.61.1.35.

Relationship between N-terminal pro-B-type natriuretic peptide and renal function: the effects on predicting early outcome after off-pump coronary artery bypass surgery

• Jo YY
• Kwak YL
• Lee J
• Choi YS

• KMID: 2092301
• DOI: http://doi.org/10.4097/kjae.2011.61.1.35

Abstract

BACKGROUND
Plasma levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) provide useful prognostic predictors in patients after cardiac surgery. However, predictive accuracy of NT-proBNP levels has varied significantly according to renal dysfunction. The purpose of this study was to assess whether preoperative NT-proBNP levels could be used as predictors of early postoperative outcomes on the basis of renal function in patients undergoing off-pump coronary artery bypass surgery (OPCAB).
METHODS
In 219 patients undergoing elective OPCAB, NT-proBNP and an estimated glomerular filtration rate (eGFR) were assessed preoperatively. All patients were divided into 3 groups according to tertiles of eGFR: the first (eGFR > or = 90 ml/min/1.73 m2), the second (90 ml/min/1.73 m2 > eGFR > or = 72 ml/min/1.73 m2) and the third tertile group (eGFR < 72 ml/min/1.73 m2). End point was the composite of early postoperative complications defined as myocardial infarction, new onset atrial fibrillation, ventricular dysfunction, prolonged mechanical ventilator care (> 48 hr), prolonged ICU stay (> or = 3 days), and in hospital mortality.
RESULTS
There was no difference in early postoperative complications among groups. A preoperative NT-proBNP level of 228 pg/ml and 302 pg/ml (sensitivity 70%, specificity 67%, P < 0.001 and sensitivity 73%, specificity 63%, P = 0.001, respectively) were optimal cut-off values predicting complicated early postoperative course in second and third tertile group, respectively.
CONCLUSIONS
Preoperative NT-proBNP levels seem to be predictive of early postoperative complications in patients with eGFR < 90 ml/min/1.73 m2 undergoing OPCAB.

Keyword

NT-proBNP; OPCAB; Renal function

MeSH Terms

Atrial Fibrillation
Coronary Artery Bypass, Off-Pump
Glomerular Filtration Rate
Humans
Myocardial Infarction
Natriuretic Peptide, Brain
Peptide Fragments
Plasma
Postoperative Complications
Sensitivity and Specificity
Thoracic Surgery
Ventilators, Mechanical
Ventricular Dysfunction
Natriuretic Peptide, Brain
Peptide Fragments