Korean J Thorac Cardiovasc Surg.  2008 Feb;41(1):55-60.

The Role of B-type Natriuretic Peptide in Predicting Postoperative Complications and Outcomes in Patients Undergoing Coronary Artery Bypass Graft

• Jung TE
• Lee DH
• Lee JH
• Do HD
• Han SS

Abstract

BACKGROUND: Circulating levels of brain natriuretic peptide (BNP) provide prognostic information for patients with heart failure. The aim of our study was to investigate whether preoperative and postoperative BNP levels could predict postoperative complications and outcomes in patients after coronary artery bypass graft (CABG). MATERIAL AND METHOD: Data was collected prospectively on 30 patients (M/F=19/11, age 60.0+/-9.6 years) undergoing conventional CABG during a 1-year period beginning on January 1, 2005. Patients underwent off-pump CABG, and combined surgery was excluded. The BNP assay was performed preoperatively, immediate postoperatively at the intensive care unit (ICU), and 1, 3, 5, and 7days postoperatively. RESULT: Preoperative BNP levels significantly correlated with preoperative echocardiographic ejection fraction and an ICU stay of 5 days or more (r=-0.4, p=0.028; r=0.39, p=0.031, respectively). A preoperative BNP cut-off value above 263 pg/mL demonstrated high specificity (90.5%) for predicting postoperative complications using the receiver operating characteristics curves. Preoperative and postoperative (7 days) BNP levels were different depending on the abscence (mean BNP=99+/-23 pg/mL vs. 296+/-74 pg/mL, p<0.05) and presence (mean BNP=212+/-29 pg/mL vs. 408+/-23 pg/mL, p<0.01).
CONCLUSION
Preoperative BNP levels > 263 pg/mL predict postoperative complications in patients receivingCABG.

Keyword

Complication; Brain natriuretic factor; Coronary artery bypass graft

MeSH Terms

Coronary Artery Bypass
Coronary Vessels
Heart Failure
Humans
Intensive Care Units
Natriuretic Peptide, Brain
Postoperative Complications
Prospective Studies
ROC Curve
Sensitivity and Specificity
Transplants
Natriuretic Peptide, Brain