Korean Circ J.  2011 Jan;41(1):11-15. 10.4070/kcj.2011.41.1.11.

Utility of B-Type Natriuretic Peptide for Predicting Perioperative Cardiovascular Events in Patients Without History of Cardiovascular Disease Undergoing Major Non-Cardiac Surgery

• Kim SE
• Park DG
• Lee JH
• Han KR
• Oh DJ

• KMID: 2225148
• DOI: http://doi.org/10.4070/kcj.2011.41.1.11

Abstract

BACKGROUND AND OBJECTIVES
Patients without previous history of cardiac disease can be regarded as low-risk when undergoing major non-cardiac surgery. The aim of this study was to examine whether preoperative B-type natriuretic peptide (BNP) level predicted postoperative cardiac events in these patients.
SUBJECTS AND METHODS
Preoperative BNP level was measured in 163 patients whose risk was considered low according to the Revised Cardiac Risk Index. Postoperative cardiac events, including death during hospitalization, myocardial injury, arrhythmia, cerebrovascular accidents and congestive heart failure were assessed.
RESULTS
Postoperative cardiac events occurred in 8 patients (4.9%). Preoperative BNP levels were significantly higher among patients who experienced postoperative cardiac events, compared to those who did not (130.6+/-148.8 vs. 57.9+/-70.8 pg/mL, p=0.009).
CONCLUSION
Preoperative BNP level may provide prognostic information in low-risk patients undergoing major non-cardiac surgery.

Keyword

B-type natriuretic peptide; Perioperative care; Cardiovascular disease

MeSH Terms

Arrhythmias, Cardiac
Cardiovascular Diseases
Heart Diseases
Heart Failure
Hospitalization
Humans
Natriuretic Peptide, Brain
Perioperative Care
Stroke
Natriuretic Peptide, Brain

Figure

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  Fig. 1 A comparison of preoperative BNP levels in patients who experienced a postoperative cardiac event (Y) with those who did not (N). Central lines represent medians, boxes represent 25th and 75th percentiles and whiskers represent ranges. BNP: B-type natriuretic peptide.

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  Fig. 2 Receiver operator characteristic curve for preoperative B-type natriuretic peptide levels predicting an early postoperative cardiac event. Area under the curve=0.76 (95% confidence interval=0.63-0.89, p=0.014). ROC: receiver-operating characteristic.

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