Korean J Anesthesiol.  2001 Dec;41(6):S33-S38. 10.4097/kjae.2001.41.6.S33.

The Potentiation of the Analgesic Effect of Intrathecally Coadministered Magnesium Sulphate and Bupivacaine in Duration of Sensory Blockade in Rats

• Choi JC
• Yoon KB
• Kim JS
• Kim SY
• Lee KH
• Lee YB
• Lim HK
• Jun ES

• KMID: 2091656
• DOI: http://doi.org/10.4097/kjae.2001.41.6.S33

Abstract

BACKGROUND: Based on previously reported articles, magnesium sulphate seemed to cause a motor paralysis, but not complete analgesia when administered intrathecally alone, but is likely to have a partial analgesic effect. Accordingly, we tested a hypothesis that magnesium sulphate might potentiate the analgesic effect when coadministered intrathecally with bupivacaine.
METHODS
Eighteen male Sprague-Dawley rats were allocated into three groups of six animals each. The duration of sensory blockade was determined by observing the period when the animal did not vocalize and/or withdraw (struggle) while forceps-pinch tests were applied to a hindlimb paw. The six animals in each of the following three groups were injected intrathecally with 0.03 ml of the different test substances: (group 1) 16.7% magnesium sulphate {50% magnesium sulphate (0.01 ml) + 0.9% sodium chloride (0.02 ml)}; (group 2) 50% magnesium sulphate (0.01 ml) + 0.5% bupivacaine (0.02 ml); (group 3) 0.33% bupivacaine {0.5% bupivacaine (0.02 ml) + 0.9% sodium chloride (0.01 ml)}.
RESULTS
Sensory blockade in the hindlimbs was observed only in group 2 and lasted for 12 to 14 minutes, while there were no sensory blockades in group 1 and group 3.
CONCLUSIONS
Magnesium sulphate potentiated the analgesic effect of bupivacaine when coadministered intrathecally with bupivacaine in rats. These results suggest that intrathecal administration of magnesium sulphate may be a useful adjunct to spinal bupivacaine anesthesia.

Keyword

Anesthetic techniques: intrathecal; Pharmacology: bupivacaine; magnesium sulphate

MeSH Terms

Analgesia
Anesthesia
Animals
Bupivacaine*
Hindlimb
Humans
Magnesium*
Male
Paralysis
Rats*
Rats, Sprague-Dawley
Sodium Chloride
Bupivacaine
Magnesium
Sodium Chloride