Korean J Anesthesiol.  2000 Dec;39(6):S17-S22. 10.4097/kjae.2000.39.6.S17.

Comparison of Liver Function after Induced Hypotension between Enflurane and Isoflurane Anesthesia in Spinal Surgery

• Park CK

• KMID: 2091588
• DOI: http://doi.org/10.4097/kjae.2000.39.6.S17

Abstract

BACKGROUND: Induced hypotension reduces blood loss in the surgical field and provides better visibility, but may produce ischemic damage to the liver. The purpose of this study is to compare liver function after induced hypotension between general anesthesia with enflurane and isoflurane in spinal surgery.
METHODS
Forty patients were randomly allocated to enflurane (group 1, n = 20) and isoflurane (group 2, n = 20) group. During operation, hypotension was induced with hydralazine to maintain systolic blood pressure between 60 to 80 mmHg in both groups. Preoperative and postoperative 1, 3, 5 and 7 days' serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) were evaluated.
RESULTS
In group 1, SGOT levels increased significantly at postoperative 1, 3 days, and SGPT levels increased significantly at postoperative 3, 5, 7 days. In group 2, SGOT levels increased significantly at postoperative 1, 3, 5, 7 days, and SGPT levels increased significantly at postoperative 3, 5, 7 days, but there was no significant difference between the groups in SGOT and SGPT levels. ALP levels decreased at postoperative 1, 3, 5 days in group 1, and at postoperative 1, 3 days in group 2; however, there was no significant difference between the groups in ALP levels except in preoperative values.
CONCLUSIONS
These results suggest that there is no difference in postoperative liver function between general anesthesia with enflurane and isoflurane in spinal surgery after induced hypotension.

Keyword

Anesthetic techniques: induced hypotension; Liver: function; Pharmacology: hydralazine

MeSH Terms

Alanine Transaminase
Alkaline Phosphatase
Anesthesia*
Anesthesia, General
Aspartate Aminotransferases
Blood Pressure
Enflurane*
Humans
Hydralazine
Hypotension*
Isoflurane*
Liver*
Pyruvic Acid
Alanine Transaminase
Alkaline Phosphatase
Aspartate Aminotransferases
Enflurane
Hydralazine
Isoflurane
Pyruvic Acid