Korean J Anesthesiol.  1990 Aug;23(4):591-598. 10.4097/kjae.1990.23.4.591.

The Effect of Intravenous Injection of Nalbuphine HCL and Morphine on the CO2 Response Curve in Normal Volunteers

• Ham BM
• Lee YS

• KMID: 2090562
• DOI: http://doi.org/10.4097/kjae.1990.23.4.591

Abstract

To compare the respiratory depressant effect of nalbuphine and morphine, six healthy male volunteers (mean age 26 yr) were given the nalbuphine at a dose of 0.15 mg/kg and morphine at a dose of 0.1 mg/kg intravenously, at intervals of 2 weeks in a double-blind laboratory study. Respiratory depression was monitored by ventilatory responses during CO2 rebreathing at 1 min, 30 min, 60 min and 90 min after injection. The displacement (mean intercept at Petco2 60 mmHg) and the slope of the linear relationship between minute ventilation with Petco2 were measured, There were no significant differences in the slope and the displacement of CO2 response curve between nalbuphine group and morphine group. Also, no significant differences in the slope and the displacement among 1 min, 30 min, 60 min and 90 min after injection of nalbuphine and morphine were noted. These findings demonstrate that the respiratory depressant effect of nalbuphine in similar to morphine at equianalgesic dose, and occurs within 10 min, and continues more than 90 min.

Keyword

Nalbuphine HC1; Morphine; CO2 response curve; slope; displacement

MeSH Terms

Healthy Volunteers*
Humans
Injections, Intravenous*
Male
Morphine*
Nalbuphine*
Respiratory Insufficiency
Ventilation
Volunteers
Morphine
Nalbuphine