Korean J Anesthesiol.
1993 Dec;26(6):1284-1288. 10.4097/kjae.1993.26.6.1284.
A Case of Withdrawal Symptom after Injection of Nalbuphine in a Chronically Morphine-Dependent Patient
- Affiliations
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- 1Department of Anesthesiology, Seoul National University Medical College, Seoul, Korea.
- 2Department of Anesthesiology, Seoul National University Dental College, Seoul, Korea.
- KMID: 1933967
- DOI: http://doi.org/10.4097/kjae.1993.26.6.1284
Abstract
- Nalbuphine, a mixed agonist-antagonist type opioid, can precipitate abstinence syndrome in opioid-dependent patients especially in large doses. We can prevent this syndrome by avoiding the injection of agonist-antagonist type opioid to the patient who already has used opioid for a long time, and the method of relatively small dose increments in its use. We experienced a case of opioid withdrawal symptom in chronically morphine-administered patient via epidural catheter after using intramuscular nalbuphine for analgesia. The symptom was promptly relieved by intravascular morphine injection without any problems.
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