Korean J Blood Transfus.  2014 Dec;25(3):291-296. 10.0000/kjbt.2014.25.3.291.

Mycophenolate Mofetil for Treatment of Autoimmune Hemolytic Anemia and Nephrotic Syndrome after Cord Blood Transplantation

• Lee JM
• Kim SY
• Kim YK

• KMID: 2090039
• DOI: http://doi.org/10.0000/kjbt.2014.25.3.291

Abstract

We report on a 2-year-old girl who developed autoimmune hemolytic anemia, which occurred with minimal change nephrotic syndrome 3 months after umbilical cord blood transplantation for acute megakaryocytic leukemia. Because the disease is regarded as chronic graft versus host disease and developed while taking cyclosporine medication, she was treated with methylprednisolone 2 mg/kg/day. However, hemolysis and proteinuria were refractory to steroid treatment. One week after starting methylprednisolone, mycophenolate mofetil was added. Hemolysis and proteinuria showed improvement after 2 weeks of mycophenolate mofetil medication.

Keyword

Cord blood stem cell transplantation; Graft versus host disease; Autoimmune hemolytic anemia; Mycophenolate mofetil; Nephrotic syndrome

MeSH Terms

Anemia, Hemolytic, Autoimmune*
Child, Preschool
Cord Blood Stem Cell Transplantation
Cyclosporine
Female
Fetal Blood*
Graft vs Host Disease
Hemolysis
Humans
Leukemia, Megakaryoblastic, Acute
Methylprednisolone
Nephrosis, Lipoid
Nephrotic Syndrome*
Proteinuria
Cyclosporine
Methylprednisolone