Korean J Blood Transfus.
2010 Aug;21(2):148-153.
New Variant of O02 Allele Found in the Family of Cis-AB: Report of Three Cases in a Family
- Affiliations
-
- 1Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea. dcho@chonnam.ac.kr
- 2Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Hwasun, Korea.
Abstract
- In preoperative ABO typing, we observed an ABO discrepancy in a 61 year-old patient with A2B3 phenotype. Standard serologic tests for the ABO blood group phenotypes and ABO gene direct sequencing for the exons 6 and 7 were done as part of the patient's family study. We found that the patient's genotype was identical to cis-AB01/O02, except for a 703 G>A polymorphism at exon 7. An allele-separation by cloning and subsequent sequencing of the heterozygote was carried out. We identified a novel O02 variant allele characterized by a 703 G>A polymorphism in the patient and in her 2 daughters.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- A Case of ABO* cis-AB01/Ax03 Found in A2B3 Phenotype
- A Case of a Family with a High Frequency of cis-AB
- Phenotype and Genotype of Cis-AB Family in Chonnam Area
- Characteristics of Intron 6 Nucleotide Sequences of cis-AB in Koreans
- Molecular Genetic Analysis of Cis-AB with Cytosine at nucleotide position 467
