Korean J Blood Transfus.
2010 Dec;21(3):230-235.
Characteristics of Intron 6 Nucleotide Sequences of cis-AB in Koreans
- Affiliations
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- 1Department of Laboratory Medicine, School of Medicine, Korea University, Seoul, Korea. malarim@korea.ac.kr
Abstract
- BACKGROUND
The cis-AB is a very rare phenotype in the ABO blood group system. It corresponds to a special ABO allele that encodes glycosyltransferase that is capable of synthesizing both A and B antigens. Until now, the exon 6 and 7 gene sequences of cis-AB alleles are well known. In this study, we report on the intron 6 sequence structure of the cis-AB allele.
METHODS
Standard serologic tests for the ABO blood group phenotypes were performed in four cis-AB samples. Allele-separation by cloning and subsequent sequencing was carried out.
RESULTS
The results showed that intron 6 of cis-AB is almost identical to the A101 allele except for three single nucleotide polymorphisms at nucleotide positions 163, 179 and 662, where the nucleotides of the A101 replace those of B101.
CONCLUSION
The intron 6 sequences of cis-AB in Koreans have both A101 and B101 blood group sequences.
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