Korean J Blood Transfus.
2007 Dec;18(3):239-243.
A Case of a Family with a High Frequency of cis-AB
- Affiliations
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- 1Department of Laboratory Medicine, College of Medicine, Dongguk University, Goyang, Korea. rockies@dongguk.ac.kr
- 2Department of Obstetrics and Gynecology, College of Medicine, Dongguk University, Goyang, Korea.
- 3Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
Abstract
- The cis-AB phenotype is relatively common in the Japanese and Korean populations. Phenotypes of cis-AB include variables such as A2B3, A2B and A1B3. A few cases of cis-AB with phenotype A1 have been reported. Recently, we experienced a case with one family member identified with phenotype A1, genotype cis-AB/A and a high frequency of cis-AB. A 34-year-old woman visited the hospital for prenatal testing. The ABO phenotype of the patient was A2B3. To confirm the presence of cis-AB, ABO typing and genotyping of the patient's family were performed. The patient's mother and father were typed as normal group O and A, respectively. The ABO genotype of the mother was identified as cis-AB/A. The four sisters and brothers were typed as cis-AB. The normal incidence of cis-AB in a family is 50%. Interestingly, ABO typing revealed that all five members of the family had cis-AB in this case.
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