Korean J Blood Transfus.  2003 Jun;14(1):28-34.

The frequency of the cis-AB blood type in blood donors in southwestern Korea

Affiliations
  • 1Department of Laboratory Medicine, Chonnam National University Medical School.
  • 2Department of Forensic Medicine, Chonnam National University Medical School.
  • 3Institute of Medical Science, Chonnam National University.
  • 4Kwangju-Chonnam Red Cross Blood Center, Gwangju, Korea.

Abstract

BACKGROUND: Cis-AB is a rare ABO blood type with an unusual inheritance, on the same chromosome that results from a point mutation. It is relatively common in Korean and Japanese populations. Although more than 100 cases of the cis-AB blood type have been reported, there is no report on the frequency of the cis-AB blood type in Korea. Therefore, we analyzed the frequency of the cis-AB blood type in blood donors in southwestern Korea.
METHODS
This study examined 111,842 samples obtained from blood donors recruited at the Gwangju-Chonnam Red Cross Blood Center between July 2002 and Oct 2002. ABO serologic tests were performed on all of the samples and ABO genotyping using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was performed on peripheral blood DNA samples from 129 cases: 24 A2B3, 81 A2B, 23 A1B3, and 1 A1Bx or el case.
RESULTS
The frequency of the cis-AB blood type was 0.0331%(37/111,842). Of the 37 cases, 24 cases were the cis-AB/O genotype with the A2B3 phenotype, 9 cases were the cis-AB/A genotype with the A2B phenotype, 3 cases were the cis-AB/B genotype with the A1B3 phenotype, and 1 case was the cis-AB/A genotype with the A1Bx or el phenotype. In the 129 cases, the cis-AB ratio was 100% (24/24), 39.1% (9/23), 3.7% (3/81), and 100% (1/1) in the A2B3, A1B3, A2B, and A1Bx or el phenotypes, respectively.
CONCLUSIONS
The frequency of the cis-AB blood type in blood donors in southwestern Korea is about 0.0331%. The most common type of cis-AB was cis-AB/O with the A2B3 phenotype. In addition, one case of cis-AB/A with an unusual A1Bx or el phenotype was found.

Keyword

Frequency; Cis-AB; southwestern Korea

MeSH Terms

Asian Continental Ancestry Group
Blood Donors*
DNA
Genotype
Humans
Korea*
Phenotype
Point Mutation
Red Cross
Serologic Tests
Wills
DNA
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