Korean J Blood Transfus.  1994 May;5(1):57-62.

A Case of Autoimmune Hemolytic Anemia in a Renal Transplant Recipient due to Anti-A of Donor Origin

• Shin YT
• Lee JK
• Min HK
• Kwon KC
• Koo SH
• Park JW
• Lee GW

Abstract

Autoimmune hemolytic anemia due to antibody formation against the A or B antigen in renal transplant recipients has been reported on rare occasions. We experienced a case of autoimmune hemolytic anemia which developed 11 days after renal transplantation during CsA and prednisolone administration as immunosuppressive agents. The patient was a 46 year old male, blood group was Rh(+) A, who had received a kidney from his Rh(+) O, HLA haploty'pe identical elder brother. He was transfused with three units of Rh(+) A RBCs preoperatively and his hemoglobin level was 9.2g/dl 1 day after transplantation. After 11 to 12 days posttransplantation, the hemoglobin level dropped to 3.8g/dl. A peripheral blood smear showed marked spherocytosis and polychromatophilia. The reticulocyte count was increased to 4.2%, and total bilirubin was increased to 2.91mg/dl. The LDH was raised to 561 IU/L and the plasma Hb level was 6.Smg/dl. Blood bank tests confirmed that the autoantibody cause hemolytic anemia was anti-A. If transplant recipients of blood groups A, B, or AB, who recieve organs from blood group 0 donors, have hemolytic anemia and ABO discrepancy, the possibility of AIHA due to anti-A or anti-B should be considered.

MeSH Terms

Anemia, Hemolytic
Anemia, Hemolytic, Autoimmune*
Antibody Formation
Bilirubin
Blood Banks
Blood Group Antigens
Humans
Immunosuppressive Agents
Kidney
Kidney Transplantation
Male
Middle Aged
Plasma
Prednisolone
Reticulocyte Count
Siblings
Tissue Donors*
Transplantation*
Bilirubin
Blood Group Antigens
Immunosuppressive Agents
Prednisolone