Blood Total Antioxidant Capacity in Patients with Stomach and Colorectal Cancer

Jeon, Chang Ho; Lee, Eun Ha; Lee, Han Il

Abstract

BACKGROUND: To evaluate the status of blood total antioxidant capacity and the association with tumor progression, we measured the blood total antioxidant capacity in patients with stomach and colorectal cancer.
METHODS
We collected 83 specimens as controls (41.3+/-17.1 yr), 42 specimens with stomach cancer patients (58.1+/-10.7 yr) and 18 specimens with colorectal cancer patients (59.6+/-11.3 yr). The samples were stored at -70degreesC for 1 month and serum antioxidant capacity, glucose, albumin, AST, ALT, cholesterol, uric acid and creatinine were measured. The patients were classified according to the stage of American Joint Committee on Cancer.
RESULTS
In the controls, the men showed 9.0% increase of average total antioxidant capacity compared to that of the women. The results of total antioxidant capacity had good correlation with that of albumin and uric acid. We detected significant decrease of total antioxidant capacity in the patients with colorectal cancer. The results of total antioxidant capacity from the patients of cancer had poor correlation with that of albumin and uric acid except for that of uric acid in the colorectal cancer patients. In the patients with stage 3 and 4 colorectal cancer, we could detect significant decrease of total antioxidant capacity.
CONCLUSIONS
According to the cancer types, measurement of total antioxidant capacity for the cancer patients could provide useful informations about tumor initiation, promotion and progression, so it would be necessary to have a regular examination of total antioxidant capacity for all patients of cancer.