Korean J Dermatol.  2000 Jan;38(1):84-89.

Two Cases of Lichen Amyloidosis Stained Negatively for Antikeratin Antibodies

• Suh DH
• Son HC
• Cho YW
• Han JY
• Song KY

Abstract

Localized primary cutaneous amyloidosis consists of three types: nodular, macular, and lichenoid amyloidosis. Lichen amyloidosis is characterized by the appearance of paroxysmally itchy lichenoid papules on the shins. Although the origin of the amyloid is controversial and can not provide any definite answer, some of amyloid substances can be derived from epidermal cells and others from degenerative collagen fibers. We suggested the origin of amyloid in our cases as epidermal keratinocyte and collagen degenerations. Because degeneration of basal keratinocyte is observed on electron microscopy and degeneration of collagen is in H&E and Masson's trichrome stain although amyloid materials are negatively stained against pankeratin antibody and collagen antibody. The skin lesion was improved after triamcinolone intralesional injections which reduce collagen synthesis. We report two cases of lichen amyloidosis which stained negatively for antikeratin antibodies and improved with triamcinolone intralesional injection.

Keyword

Lichen amyloidosis; Antikeratin antibodies

MeSH Terms

Amyloid
Amyloidosis*
Antibodies*
Collagen
Injections, Intralesional
Keratinocytes
Lichens*
Microscopy, Electron
Skin
Triamcinolone
Amyloid
Antibodies
Collagen
Triamcinolone