Korean J Dermatol.  1997 Aug;35(4):809-813.

A Case of Pyoderma Gangrenosum on the Hand related to Myelofibrosis

• Kim DY
• Won YH
• Kim SJ
• Lee SC
• Chun IK

Abstract

Pyoderma gangrenosum is a rare neutrophilic dermatosis manifesting as painful pustules or bullae, which rapidly become necrotic to produce an ulceration. It is often associated with systemic disease, such as inflammatory bowel disease, rheumatoid arthritis, leukemia, but myelofibrosis is reported rarely for its underlying disease. The most common location is the lower extremities, and the pyoderma gangrenosum also occur infrequently on the hand and face. As in our case, bilateral involvement of the hands are rarely reported. We present a case of pyoderma gangrenosum that had developed on both hands in a 66 year old man who had macrocytic,anemia. A bone marrow biopsy revealed proliferation of fibroblasts and a dense reticulin network consistent with myelofibrosis, the association of which is very rare world wide.

Keyword

Pyoderma gangrenosum; Myelofibrosis; Hand

MeSH Terms

Aged
Arthritis, Rheumatoid
Biopsy
Bone Marrow
Fibroblasts
Hand*
Humans
Inflammatory Bowel Diseases
Leukemia
Lower Extremity
Neutrophils
Primary Myelofibrosis*
Pyoderma Gangrenosum*
Pyoderma*
Reticulin
Skin Diseases
Ulcer
Reticulin