Korean J Dermatol.  1997 Aug;35(4):781-785.

Pyoderma Gangrenosum Associated with Idiopathic Myelofibrosis

• Choi TJ
• Kwon YH
• Yoon DH
• Kim TY
• Kim CW

Abstract

Pyoderma gangrenosum is a rare, recurrent, painful and ulcerative skin disorder of unknown etiology, but is commonly associated with a variety of underlying systemic diseases of ulcerative colitis, rheumatoid arthritis, monoclonal gammopathies, Crohns disease, chronic active hepatitis and some hematologic diseases such as leukemia, thrombocythemia, dysglobulinemia and myeloma. We describe a 50 year-old woman who had pyoderma gangrenosum associated with idiopathic myelofibrosis. The findings of a bone marrow biopsy revealed proliferation of fibroblasts and a dense reticulin network, which were consistent with myelofibrosis. Steroid therapy resulted in a good response temporarily but, she died within a year after diagnosis. To our knowledge, our present case associated with idiopathic myelofibrosis is the first reported case in the Korean literature.

Keyword

Pyoderma gangrenosum; Idiopathic myelofibrosis

MeSH Terms

Arthritis, Rheumatoid
Biopsy
Bone Marrow
Colitis, Ulcerative
Crohn Disease
Diagnosis
Female
Fibroblasts
Hematologic Diseases
Hepatitis, Chronic
Humans
Leukemia
Middle Aged
Paraproteinemias
Primary Myelofibrosis*
Pyoderma Gangrenosum*
Pyoderma*
Reticulin
Skin
Thrombocytosis
Ulcer
Reticulin