Promotion of Gallbladder Emptying by Rapid Intravenous Aminoacids In fusion

Chang, Jae Nam; Yi, Jae Su; Kim, Myong Sik; Oh, Yoon Ju; Kim, In Han; Kwon, Kye Sook; Kim, Mi Young; Kim, Pum Soo; Lee, Don Haeng; Cho, Hyun Keun; Choi, Won; Kim, Hyung Gil; Shin, Yong Woon; Kim, Young Soo

Abstract

BACKGROUND/AIMS: Gallbladder (GB) sludges and/or gallstones frequently develop due to hypomo tility of GB after long-term total parenteral nutrition, abdominal surgery, bone marrow transplantata tion, AIDS infection, trauma. The purpose of this study is to promote GB contraction and emptying with the rapid intravenous infusion of aminoacids and then, to determine the most effective dosage and infusion rate.
METHODS
After infusion of aminoacids, the volume of GB was measured serially using ultrasonography before infusion and immediately (0 min), 15 min, 30 min, 45 min and 60 min after infusion. The subjects of this study were 28 healthy male volunteers aged from 23 to 26. For control group (n=4), 250 cc of normal saline was infused for 30 min. For group A (n=8), 250 cc o aminoacids solution was infused for 30 min (21.2 g, 0.7 g/min). For group B (n=8), 250 cc o aminoacids solution was infused for 10 min (21.2 g, 2.1 g/mn). For group C (n=8), 125 cc o aminoacids solution was infused for 5 min (10.6 g, 2.1 g/min).
RESULTS
The volume of GB was significantly decreased with the lapse of time in A, B, C groups and the most significant change occurred at 45 min after infusion (p=0.0001). These groups showed significant volume change com pared to control group (p=0.0029). At 15 min after infusion, significant GB contraction occurred in group B, C compared to control group (p=0.0030). Only B group showed significant GB contraction at 45 min after infusion (p=0.0041).
CONCLUSIONS
It is concluded that the intermittent rapid intravenous minoacids infusion may be useful to prevent GB sludges in the high risk groups.