Low-grade Gastric B-cell Lymphoma of Mucosa-Associated Lymphoid Tissue

Min, Young Il; Kim, Byung Sik; Park, Kun Choon; Yu, Eun Sil; Yook, Jeong Hwan; Jung, Hwoon Yong; Oh, Sung Tae; Kim, Wan Soo; Kim, Hee Cheol; Kim, Sang Hee

Abstract

BACKGROUND AND AIMS: The great majority of primary gastric lymphomas are B-cell origin. Unlike nodal B-cell lymphomas, low-grade B-cell lymphomas of the stomach recapitulate the features of mucosa-associated lymphoid tissue (MALT) and are the paradigm for the MALT lymphoma group. This study was perfarmed to determine the clinical behaviors of gastric MALT lymphoma and to decide the optimal treatment modalities.
METHODS
The retrospective study and pathologic review of 18 patients with gastric MALT lymphomas were performed.
RESULTS
The rnedian age was 47 years (range, 33-63 years). There were 11 men and 7 women. Tumor stage of the patients were classified according to the Ann-Arbor staging system. The 72% of patients were in stage IE, 11% in IIE, 6% in IIIE and 11% in IVE. Eleven patients received resection. Among them, 7 patients received postoperative adjuvant chemotherapy and 2 patients received postoperative radiotherapy. Among the other 7 cases three patients received chemotherapy, only. One patient received chemotherapy combined with antibiotics far eradication of H. pylori and the remaining three patients received antibiotic therapy only. In the 11 resected cases, there were 8 cases in T1, 1 in T2, 2 in T3 and 8 in NO, 1 in N1, 2 in N2 according to the AJCC staging system for the gastric adenocarcinoma. The median of follow-up period was 16 months (range, 3-65 months). All cases except 1 case treated with the bone marrow permeation at initial diagnosis were survived. The recurrence occurred in one case that received antibiotic therapy, but complete remission was obtained after retrial of antibiotics.
CONCLUSIONS
We conclude that the resection is considered for the treatment of MALT lymphomas especially with deep penetration of stomach wall and perigastric node metastasis.