Korean J Helicobacter Up Gastrointest Res.  2015 Mar;15(1):27-32. 10.7704/kjhugr.2015.15.1.27.

The Optimal Commencement Time of Helicobacter pylori Eradication in Bleeding Peptic Ulcer Disease

• Choi SH
• Bang CS
• Baik GH
• Kim SH
• Kim HS
• Park SH
• Kim EJ

• KMID: 2083682
• DOI: http://doi.org/10.7704/kjhugr.2015.15.1.27

Abstract

BACKGROUND/AIMS
Helicobacter pylori eradication promotes healing and prevents recurrence of H. pylori associated peptic ulcer disease (PUD). However it is unclear whether H. pylori eradication therapy commenced on the initial course of treatment is more effective compared to therapy at a later course of treatment. We evaluated the optimal commencement time of eradication of H. pylori in patients with hemorrhagic PUD.
MATERIALS AND METHODS
Between June 2002 through July 2013, a total of 486 patients who had hemorrhagic PUD were retrospectively evaluated. After exclusion, 79 patients who received H. pylori eradication therapy were assessed.
RESULTS
Thirty patients with duodenal ulcer (38%) and 49 patients with gastric ulcer (62%) were enrolled. The overall eradication rate were 96.2%. The eradication rates of early eradication vs. late eradication (divided by standards of 3 days after diagnosis of PUD) were 94.3% vs. 100%, and was not significantly different (P=0.55).
CONCLUSIONS
According to our study, medication commencement time does not have an effect on the eradication rate of H. pylori infection in patients with hemorrhagic PUD.

Keyword

Helicobacter pylori; Peptic ulcer

MeSH Terms

Diagnosis
Duodenal Ulcer
Helicobacter pylori*
Hemorrhage*
Humans
Peptic Ulcer*
Recurrence
Retrospective Studies
Stomach Ulcer