Analysis of the Mean Peroxidase Index for Iron Deficiency Anemia Patients using the Hematology Autoanalyzer Technicon H*2

Park, Geon; Park, Young Jin; Lee, Sung Hyun; Jang, Sook Jin; Moon, Dae Soo

Abstract

BACKGROUND: Myeloperoxidase (MPO) activity is reduced in iron depletion. MPXI (mean peroxi-dase index) can replace MPO activity as a hematologic parameter in laboratory medicine. We tried to discuss MPXI in iron deficiency anemia (IDA) that was performed with the hematology autoana-lyzer H*2.
METHODS
We studied 58 cases of normal control and 53 cases of IDA that showed the complete absence of iron storage in bone marrow. These cases included 17 cases (group I) which did not have any inflammation, or neoplasm and did not use drugs. There were 36 cases (group II) with inflammation, neoplasm and used drug. We also investigated the hematologic parameters and MPXI in 7 cases among 53 previous cases of IDA for follow- up study after iron replacement. The correlations among hematologic, iron parameters and MPXI were investigated in group I and group II.
RESULTS
Group I MPXI (-7.7 +/- 3.4) and group II MPXI (-6.4 +/- 3.6) were statistically lower than the normal control MPXI (1.3 +/- 3.6) (P<0.001). Group I MPXI was correlated with Hb, MCV, MCH, MCHC, HDW, serum iron, transferrin saturation rate and serum ferritin (P<0.05) but was not correlat-ed with age, RDW, WBC, platelet count and transferrin binding capacity. Group II MPXI was not correlated with other hematologic or iron parameters. The normal control MPXI was not correlated with other normal controls, hematologic or iron parameters. After iron replacement, the MPXI, hemoglobin and RBC indices tended to increase and HDW tended to decrease in the follow-up IDA.
CONCLUSIONS
MPXI reduced in iron deficiency anemia and appeared to be affected by various state of the patients. MPXI increased after iron replacement, which suggested that MPO activity was restored.