Korean J Med.  2007 Jun;72(6):673-678.

A case of trousseaus syndrome associated with adenocarcinoma of the lung

Affiliations
  • 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Korea. cgyoo@snu.ac.kr

Abstract

In 1865, Armand Trousseau recognized the first relationship between a neoplastic disease and a thromboembolic disorder. Since then, many cases have been reported and have been termed as Trousseau's syndrome. One mechanism of hypercoagulability was considered to be the activation of coagulation systems by a tissue factor secreted by neoplastic cells, but accurate pathophysiology still remains unknown. We report a case of a multiple and recurrent thromboembolism in a patient with adenocarcinoma of the lung. A woman aged 68 years with an acute thromboembolism at her right distal calf artery was diagnosed as having adenocarcinoma of the lung. She underwent a thromboembolectomy two times, but had to receive surgery for a below knee amputation. Multiple and recurrent thromboembolic events then attacked her cerebral and coronary arteries, which led to cerebral and myocardial infarctions. She expired by a progression of the adenocarcinoma of the lung after about six months.

Keyword

Adenocarcinoma; Lung; Trousseau's syndrome

MeSH Terms

Adenocarcinoma*
Amputation
Arteries
Coronary Vessels
Female
Humans
Knee
Lung*
Myocardial Infarction
Thromboembolism
Thrombophilia
Thromboplastin
Thromboplastin
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