Korean J Med.  2005 Oct;69(4):446-450.

A case of plasmablastic lymphoma in the nasal cavity in a human immunodeficiency virus-negative patient

• Kim TS
• Kang JM
• Kim HW
• Kim YG
• Huh J
• Jang YJ
• Suh C

Abstract

Plasmablastic lymphoma is a recently identified entity that is considered to be a type of diffuse large B-cell lymphoma with a unique immunophenotype and a predilection for the oral cavity of human immunodeficiency virus (HIV) positive patients. We report a case of plasmablastic lymphoma presenting in nasal cavity of a 48-year-old, HIV-negative man. Cytologic and histologic examinations demonstrated a large cell lymphoma with plasmablastic differentiation. The tumor cells were positive for CD138, epithelial membrane antigen, but lacked expression of leukocyte common antigen, T-cell, and B-cell markers. Abundant Epstein-Barr virus-encoded RNA transcripts were identified by in situ hybridization. The lambda-light-chain restriction was demonstrated by in situ hybridization. These findings were compatible with plasmablastic lymphoma. Subsequent whole body FDG-PET scan revealed hypermetabolic lesions in the nasal cavity and left cervical lymph nodes level II,III,IV. To our knowledge, this is the first case of plasmablastic lymphoma in Korea.

Keyword

Lymphoma; Large cell; Plasmablastic; HIV-negative; Nasal cavity

MeSH Terms

Antigens, CD45
B-Lymphocytes
HIV
Humans*
In Situ Hybridization
Korea
Lymph Nodes
Lymphoma*
Lymphoma, B-Cell
Middle Aged
Mouth
Mucin-1
Nasal Cavity*
RNA
T-Lymphocytes
Antigens, CD45
Mucin-1
RNA