Korean J Med.  2000 Sep;59(3):261-267.

Extra-gastric MALT lymphoma: Analysis of 50 cases

• Oh SY
• Kim WS
• Kim JH
• Song SY
• Kim KH
• Nam EM
• Koh YH
• Ree HJ
• Kim YD
• Ahn YC
• Kang WG
• Yoon SS
• Lee HG
• Park CH
• Park KC

Abstract

BACKGROUND: Mucosa-associated lymphoid tissue(MALT) lymphoma has an indolent natural course. However, extra-gastric MALT lymphoma has been reported to have more frequent relapses and shorter time to progress than gastric MALT lymphoma. We performed this study to analyze clinical features of extra-gastric MALT lymphoma.
METHODS
We retrospectively reviewed the medical records of the patients who were diagnosed as extra-gastric MALT lymphoma at the Samsung Medical Center from March 1995 to January 1999. The survival was analyzed by Kaplan-Meier method.
RESULTS
During the study period, extra-gastric MALT lymphoma was diagnosed in 50 patients. The median age was 51(28-87)yaers. The male to female ratio was 22:28. Commonly involved sites were conjunctiva (25/50, 50%), lung (6/50, 12%) and intestine(6/50, 12%). Histopathologically, low to high grade ratio of extra-gastric MALT lymphoma was 47:3. Among 41 patients who were staged, 32 patients(78%) had stage I or II and 9 patients(22%)had stage IV. B symptoms were seen in only 3 patients. Bone marrow involvement was observed in 4 patients. The duration of median follow up was 22 months. The 1-year and 2-year survival rates were 95.1% and 91.4% retrospectively.
CONCLUSION
Majoity of our cases with extra-gastric MALT lymphoma had low grade, early stage, good treatement reponse and good prognosis.

Keyword

Lymphoma; Mucosa - associated lymphoid tissue

MeSH Terms

Bone Marrow
Conjunctiva
Female
Follow-Up Studies
Humans
Lung
Lymphoma
Lymphoma, B-Cell, Marginal Zone*
Male
Medical Records
Prognosis
Recurrence
Retrospective Studies
Survival Rate