Korean J Nephrol.
2003 Sep;22(5):546-551.
Urinary Transforming Growth Factor-beta1 (TGF-beta1)/Creatinine Ratio and Its Clinical Implications in Childhood Acute Pyelonephritis
- Affiliations
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- 1Department of Pediatrics, College of Medicine, Ulsan University, Asan Medical Center, Seoul, Korea.
- 2Department of Pediatrics, College of Medicine, Pocheon, CHA University, Pocheon, Korea.
- 3Department of Pediatrics, Seoul National University, College of Medicine, Seoul, Korea. ilsooha@snu.ac.kr
Abstract
- BACKGROUND
Pyelonephritis is one of the major causes of chronic renal failure in children, and the transforming growth factor-beta1 (TGF-beta1) is a molecule with pivotal roles in fibrogenesis. This study was performed to investigate the alteration and clinical implications of urinary TGF-beta1/creatinine ratio in children with acute pyelonephritis. METHODS: Urine was collected from 67 normal children and 25 children with acute pyelonephritis. After routine urinalysis, urine TGF-beta1 was quantitated by ELISA method and creatinine was measured by alkaline picrate method. Urinary TGF-beta1/ creatinine ratios in children with pyelonephritis were compared with those of age-matched controls, and sequential changes of the ratios in pyelonephritic children were traced after antibiotic treatment. Correlation of urinary TGF-beta1/creatinine ratio with the degree of pyuria and renal scar was analyzed each. RESULTS: Neonates showed higher urinary TGF-beta1/creatinine ratios than older children. The ratio increased in acute pyelonephritis and gradually returned to the control level two days after antibiotic treatment. Urinary TGF-beta1/creatinine ratio in acute pyelonephritis was not correlated with the degree of pyuria and renal scar. CONCLUSION: The age should be considered in evaluation of urinary TGF-beta1/creatinine ratio in children. The ratio increases in acute pyelonephritis, and is independent of the degree of pyuria or renal scarring.
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