Korean J Obstet Gynecol.  2012 Feb;55(2):123-126. 10.5468/KJOG.2012.55.2.123.

A case of growing teratoma syndrome in mixed germ cell tumors of the ovary

• Lee Y
• You JY
• Choi CH
• Kim BG
• Bae DS
• Lee JH

• KMID: 2078126
• DOI: http://doi.org/10.5468/KJOG.2012.55.2.123

Abstract

Growing teratoma syndrome (GTS) is an increase in tumor size containing only mature teratoma component, during or after chemotherapy for germ cell tumors. A surgical resection is important to confirm diagnosis and is considered as the most appropriate therapeutic management. GTS is rare event in association with ovarian germ cell tumors. In this report, we present a case of GTS which occurred following the treatment of mixed ovarian germ cell tumor with immature teratoma and endodermal sinus tumor. The patient was given adjuvant chemotherapy consisting of six cycles of etoposide and cisplatin. Abdomen pelvis computed tomography performed after chemotherapy demonstrated no evidence of recurrence. She is on regular follow up and remained disease-free for 8 months following second surgery.

Keyword

Growing teratoma syndrome; Mixed germ cell tumor; Ovary

MeSH Terms

Abdomen
Chemotherapy, Adjuvant
Cisplatin
Endodermal Sinus Tumor
Etoposide
Female
Follow-Up Studies
Germ Cells
Humans
Neoplasms, Germ Cell and Embryonal
Ovary
Pelvis
Recurrence
Teratoma
Cisplatin
Etoposide

Figure

• 

  Fig. 1 Abdomen pelvic computed tomography shows about 14.1 × 9.1 cm sized huge cystic and solid mass in the pelvic and abdominal cavity with fine calcification.

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  Fig. 2 Immature teratoma showing squamous epithelial component and immature mesenchymal stromal component (H&E, ×200).

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  Fig. 3 Endodermal sinus tumor showing Loose reticular pattern and round papillary process with central capillary (Schiller-Duval body) (arrow, H&E, ×200).

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  Fig. 4 Post bleomycin, etoposide and cisplatin therapy, abdominopelvic computed tomography shows no interval change of residual cancer in both ovaries with peritoneal carcinomatosis.

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