A Clinical Study of Malignant Germ Cell Tumor of Ovary

Lee, S W; Lee, S K; Cho, Y J; Kim, B S; Yoon, H H; Choi, H W; Kim, S B

Abstract

A clinical study was made on 20 cases of malignant germ cell tumors that were treated at the Department of Obstetrics and Gynecology in Kyunghee University Hospital between January 1979 and December 1996. The cases of malignant germ cell tumor were 20 cases and the frequency of malignant germ cell tumor was 1.52% among ovarian tumors in this period. The mean age was 24 years. Malignant germ cell tumors classified by histologic type were 8 cases with immature teratoma, 7 cases with dysgerminoma, 3 cases with endodermal sinus tumor, 1 case with embryonal carcinoma, 1 case with teratoma with malignant change, and 1 case with mixed germ cell tumor. Sixty percent of the patients were FIGO stage I at the time of initial diagnosis. All patients were underwent operation and 13 patients were treated with adjuvant combination chemotherapy (BEP, VBP, VAC). The actuarial 5-year survival rate was 81.82% and significantly prognostic factors were stage, laterality, residual mass and pathologic diagnosis.