Korean J Obstet Gynecol.  2012 Feb;55(2):89-97. 10.5468/KJOG.2012.55.2.89.

Anti-Mullerian hormone, follicle-stimulating hormone, antral follicle count, and clinical findings as predictive markers of menopause in late reproductive-aged women

Affiliations
  • 1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. seokhyun@snu.ac.kr
  • 2Seoul National University Hospital Health Care System Gangnam Center, Seoul, Korea.
  • 3Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Korea.
  • 4Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 5Hamchoon Women's Clinics, Seoul, Korea.

Abstract


OBJECTIVE
To assess the efficiency of anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol, antral follicle count (AFC), endometrial thickness (EMT), and clinical findings as predictive markers of menopause in late reproductive-aged Korean women.
METHODS
A cohort of 104 women, aged 45 to 55 years in their menopausal transition were selected. The participants were assessed twice (T1 and T2) at a mean interval of 13.1 months. At each time, their menstrual history was determined; pelvic ultrasonography was performed to evaluate AFC and EMT; blood sampling was done. A logistic regression analysis using the SPSS ver. 17.0 was performed, with the outcome measure of menopause at T2.
RESULTS
Of the 104 participants, 33 were postmenopausal based on their menstrual history at T2. Compared with women who stayed in the menopausal transition period, those who became postmenopausal at T2 differed significantly with regard to the following factors at T1: FSH, estradiol, EMT, AFC, days from the last menstrual cycle, and interval between the last 2 cycles. However, AMH levels were not different between the groups. Of all the parameters, a longer number of days from the last menstrual cycle and time interval between the last 2 cycles were significantly associated with the occurrence of menopause.
CONCLUSION
This study indicates that AMH is not a predictive marker of menopause in late reproductive-aged women over a relatively short timeframe (range, 0.5 to 2.5 years). Time since the last menstruation at T1 was a better predictor of menopause.

Keyword

Menopausal transition period; Anti-Mullerian hormone; Follicle stimulating hormone; Antral follicle count; Last menstrual period

MeSH Terms

Aged
Anti-Mullerian Hormone
Carbamates
Cohort Studies
Estradiol
Female
Follicle Stimulating Hormone
Humans
Logistic Models
Menopause
Menstrual Cycle
Menstruation
Organometallic Compounds
Outcome Assessment (Health Care)
Anti-Mullerian Hormone
Carbamates
Estradiol
Follicle Stimulating Hormone
Organometallic Compounds

Figure

  • Fig. 1 Receiver operating characteristic (ROC) curves of selected markers after multiple logistic regression analysis for predicting menopause at T2. MCD, menstrual cycle day; LMP, last menstrual period; PMP, previous menstrual period.


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