Korean J Obstet Gynecol.  2001 Nov;44(11):1953-1960.

The Effect of Vascular Endothelial Growth Factor and basic Fibroblast Growth Factor on the Growth of Endometrial Stromal Sarcoma

• Jeong J
• Oh ST

Abstract

OBJECTIVE
In order to investigate the role of VEGF and bFGF in endometrial stromal sarcoma(ESS).
METHODS
We studied the effect of VEGF and bFGF on proliferation of endometrial stromal sarcoma cell after adding VEGF and bFGF into a culture system by autoradiography. The incorporation of [H3]-thymidine into cellular DNA was used as an index of cellular proliferation.
RESULTS
VEGF and bFGF significantly stimulated the proliferation of endometrial stromal sarcoma cells. The comparison of the effects of VEGF and bFGF showed that there was slightly more potent growth effects on endometrial stromal sarcoma cells with bFGF however, there was no stastistical significance.
CONCLUSION
Taken together, these results suggest that VEGF and bFGF play an essential role in endometrial stromal sarcoma growth and our data adds new insights in the pathogenesis of ESS. This suggests that the involvement of growth factors may not only angiogenesis, but also play a critical role in controlling ESS cell growth.

Keyword

endometrial stromal sarcoma cell; vascular endothelial growth factor; basic fibroblast growth factor; index of cellular proliferation

MeSH Terms

Autoradiography
Cell Proliferation
DNA
Fibroblast Growth Factor 2*
Intercellular Signaling Peptides and Proteins
Sarcoma, Endometrial Stromal*
Vascular Endothelial Growth Factor A*
DNA
Fibroblast Growth Factor 2
Intercellular Signaling Peptides and Proteins
Vascular Endothelial Growth Factor A