Korean J Pathol.  2000 Jun;34(6):475-479.

Malignant Granular Cell Tumor of the Shoulder: A case report

• Chung JH
• Lee JH
• Nam JH
• Choi C
• Lee MC

Abstract

A malignant granular cell tumor (MGCT) occurred in the left shoulder of a 62-year-old man. The patient underwent wide marginal excision followed by chemotherapy and radiotherapy. A metastatic tumor was identified in the axillary lymph node 22 months after the excision of the shoulder mass. The primary tumor was a poorly circumscribed mass measuring 5 5 4 cm. On cut section, it was a solid mass with yellowish tan color. Histologically, both primary and metastatic tumor consisted of polygonal cells with abundant granular cytoplasm and a vesicular nucleus with a prominent nucleolus. Two to three mitotic figures per ten high power fields at 200 were counted. Tumor cells were weakly stained with periodic acid-Schiff (PAS) preparation both before and after diastase digestion, and were positive for S-100 protein, neuron-specific enolase (NSE), and vimentin. By electron microscopy, the cytoplasm was filled with numerous autophagolysosomes containing myelin figures, mitochondria, and fragmented rough endoplasmic reticula. Basal laminae and angulated bodies were also noted. These findings suggest schwannian differentiation of this tumor.

Keyword

Malignant granular cell tumor; Immunohistochemistry; Ultrastructure

MeSH Terms

Amylases
Basement Membrane
Cytoplasm
Digestion
Drug Therapy
Granular Cell Tumor*
Humans
Immunohistochemistry
Lymph Nodes
Microscopy, Electron
Middle Aged
Mitochondria
Myelin Sheath
Phosphopyruvate Hydratase
Radiotherapy
S100 Proteins
Shoulder*
Triacetoneamine-N-Oxyl
Vimentin
Amylases
Phosphopyruvate Hydratase
S100 Proteins
Triacetoneamine-N-Oxyl
Vimentin