Korean J Pediatr.  2004 Oct;47(10):1031-1035.

Factors Involved in Lung Development and Alveolarization

• Park MS

Abstract

Lung development is a sum of processes that involve harmonized orchestration of expressions of various factors in time and space. The mastermind governing these phenomena is not known, but cumulative efforts so far have helped us gain some insights as to what are involved in and how complex the developmental process is. Beginning as primitive foregut, lungs undergo processes called branching morphogenesis and alveolarization to attain complex structures that enable effective gas exchange through conducting airways and acini. Some transcription factors, peptide growth factors, extracellular matrix proteins, and integrin and related factors are among many factors that are known to be involved. They are spatially localized and compartmentalized to render specific actions such as cellular proliferation, differentiation and apoptosis, meanwhile timely expressions of the same factors at specified time intervals are essential. Some are expressed in epithelial cells whereas others in mesenchymal cells; the crosstalks among them seem critical in coordination of developmental processes. Understanding these molecular mechanisms of lung development under normal and abnormal conditions may help devise methods to prevent as well as to revert aberrant development seen in many clinical conditions known as bronchopulmonary dysplasia, pulmonary fibrosis, and emphysema.

Keyword

Lung development; Alveolarization; Branching morphogenesis; Epithelial-mesenchymal interaction; Bronchopulmonary dysplasia

MeSH Terms

Apoptosis
Bronchopulmonary Dysplasia
Cell Proliferation
Emphysema
Epithelial Cells
Extracellular Matrix Proteins
Humans
Infant, Newborn
Intercellular Signaling Peptides and Proteins
Lung*
Morphogenesis
Pulmonary Fibrosis
Transcription Factors
Extracellular Matrix Proteins
Intercellular Signaling Peptides and Proteins
Transcription Factors