Korean J Pediatr Hematol Oncol.
2005 Oct;12(2):330-334.
Successful Treatment of Disseminated Fusariosis with Liposomal Amphotericin B and Voriconazole in a Child Undergoing Chemotherapy
- Affiliations
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- 1Department of Pediatrics, Chungbuk National University College of Medicine, Cheongju, Korea. jyk@chungbuk.ac.kr
- 2Department of Dermatology, Chungbuk National University College of Medicine, Cheongju, Korea.
- 3Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea.
- 4Pediatric Oncology Branch, National Cancer Center, Goyang, Korea.
Abstract
- Fusarium species are common soil saprophytes and plant pathogens. In humans, several species have been recognized as agents of superficial infections. Disseminated Fusariosis have been increasingly described in immunocompromised patients, especially in neutropenic patients. The prognosis is very poor despites antifungal therapy. This is the report of Fusarium oxysporum infection in a 6-year-old patient with relapsed acute leukemia and prolonged neutropenia. The patient presented with persistent fever and multiple erythematous papules with central necrosis or vesicle. Fuasrium oxysporum was isolated and cultured from a skin biopsy specimen. Initially, the patient failed to respond to conventional amphotericin B but recovered after treatment was switched to liposomal amphotericin B and voriconazole.
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