Korean J Perinatol.  2013 Dec;24(4):237-243. 10.14734/kjp.2013.24.4.237.

Effect of Indomethacin Treatment in Full-term Infants with Symptomatic Patent Ductus Arteriosus

• Kim HK
• Choi IS
• Cho HJ
• Song ES
• Cho YK
• Choi YE
• Choi YY
• Ma JS

• KMID: 2072299
• DOI: http://doi.org/10.14734/kjp.2013.24.4.237

Abstract

PURPOSE
Indomethacin has been reported as the prophylaxis and initial treatment of preterm infants with patent ductus arteriosus (PDA). However, there was controversy over indomethacin treatment in full-term infants with symptomatic PDA. Therefore, we evaluate the effect of indomethacin as a treatment of full-term infants with symptomatic PDA.
METHODS
A retrospective study was performed to evaluate the effectiveness of indomethacin in full-term infants who had birth weight > or =2,500 g and a gestational age > or =37 weeks with symptomatic PDA at Chonnam National University Hospital between January 2007 and December 2009. According to responsiveness of indomethacin, we classified them into three groups: 1) complete responder which were completely closed after indomethacin treatment, 2) partial responder which were incompletely closed but symptoms were improved, 3) non responder which were conducted surgical ligation because did not respond.
RESULTS
Among the total 29 full-term infants treated with indomethacin, 13 (44.8%) were complete responder, 8 (27.6%) were partial responder, and 8 (27.6%) were non responder. There were no significant differences in birth weight, narrow diameter of PDA, and dose of indomethacin between three groups. However, the age at initiation of treatment using indomethacin of complete (4.8+/-4.5 days, P=0.03) and partial responder (6.3+/-2.0 days, P=0.04) were earlier than those of non responder (13.8+/-8.1 days).
CONCLUSION
Indomethacin can expect an effective treatment of PDA in full-term infants prior to surgical ligation.

Keyword

Indomethacin; Patent ductus arteriosus; Full-term infants

MeSH Terms

Birth Weight
Ductus Arteriosus, Patent*
Gestational Age
Humans
Indomethacin*
Infant*
Infant, Newborn
Infant, Premature
Jeollanam-do
Ligation
Retrospective Studies
Indomethacin

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