J Korean Med Sci.  2014 Nov;29(11):1550-1554. 10.3346/jkms.2014.29.11.1550.

Efficacy and Tolerability of Anticholinergics in Korean Children with Overactive Bladder: A Multicenter Retrospective Study

Affiliations
  • 1Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
  • 2Department of Urology, Soonchunhyang University Hospital, College of Medicine, Soonchunhyang University, Bucheon, Korea.
  • 3Department of Urology, Seoul National University College of Medicine, Seoul, Korea.
  • 4Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • 5Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. scpark@amc.seoul.kr
  • 6Department of Urology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
  • 7Department of Urology, Sungkyunkwan University School of Medicine, Samsung Changwon Hospital, Chnagwon, Korea.
  • 8Department of Urology, Sunkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
  • 9Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • 10Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea.
  • 11Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
  • 12Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea.
  • 13Department of Pediatrics, Chungbuk National University College of Medicine, Cheongju, Korea.
  • 14Department of Urology, Dong-A University, Busan, Korea.
  • 15Department of Urology, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea.

Abstract

We investigated the efficacy and tolerability of various anticholinergics in Korean children with non-neurogenic overactive bladder (OAB). A total of 326 children (males:females= 157:169) aged under 18 yr (mean age 7.3+/-2.6 yr) who were diagnosed with OAB from 2008 to 2011 were retrospectively reviewed. The mean duration of OAB symptoms before anticholinergic treatment was 16.9+/-19.0 months. The mean duration of medication was 5.6+/-7.3 months. Urgency urinary incontinence episodes per week decreased from 1.9+/-3.1 to 0.4+/-1.5 times (P<0.001). The median voiding frequency during daytime was decreased from 9.2+/-5.4 to 6.3+/-4.2 times (P<0.001). According to 3-day voiding diaries, the maximum and average bladder capacity were increased from 145.5+/-66.9 to 196.8+/-80.3 mL and from 80.8+/-39.6 to 121.8+/-56.5 mL, respectively (P<0.001). On uroflowmetry, maximum flow rate was increased from 17.6+/-8.4 to 20.5+/-8.2 mL/sec (P<0.001). Adverse effects were reported in 14 (4.3%) children and six children (1.8%) discontinued medication due to adverse effects. Our results indicate that anticholinergics are effective to improve OAB symptoms and tolerability was acceptable without severe complications in children.

Keyword

Overactive Urinary Bladder; Urinary Incontinence; Anticholinergics; Efficacy; Tolerability

MeSH Terms

Child
Child, Preschool
Cholinergic Antagonists/adverse effects/*therapeutic use
Constipation/etiology
Dizziness/etiology
Female
Humans
Male
Retrospective Studies
Treatment Outcome
Urinary Bladder, Overactive/*drug therapy
Cholinergic Antagonists

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