J Korean Neurol Assoc.  2000 Sep;18(5):535-543.

Comparison of Perfusion- and Diffusion-weighted MRI in Acute Ischemic Stroke

Affiliations
  • 1Department of Neurology, College of Medicine, Kyung Hee University, Seoul, Korea.
  • 2Department of Radiology, Yonsei University Medical College, Seoul, Korea.

Abstract

BACKGROUND: Perfusion imaging (PI) of magnetic resonance imaging (MRI) uses the signal loss that occurs during dynamic tracking of the first pass of intravenous paramagnetic contrast agent. Then different hemodynamic measurements can be calculated and displayed as perfusion maps. Diffusion-weighted imaging (DWI) measures diffusional movement of water molecules within the brain and it can identify acute ischemic injury or cytotoxic edema. We evaluated clinical usefulness of PI and DWI in acute ischemic stroke.
METHODS
Fifteen patients with clinical diagnosis of acute cerebral infarction were imaged with PI, DWI, and magnetic resonance angiogram (MRA) including FLAIR within 24 hours after onset. Comparisons were made between infarct volumes measured by DWI and PI using the parameters including relative mean transit time (rMTT) map, relative cerebral blood volume (rCBV) map, and relative cerebral blood flow (rCBF) map.
RESULTS
Two patterns were found. rMTT map in PI lesion is larger than in the DWI lesion (n=7/15), and rMTT map in PI lesion is the same size or smaller than in DWI lesion (n=8/15). The former pattern was shown in cases with severe stenosis or occlusion of the major cerebral artery (MCA, PCA, or ICA) on MRA. The majority of latter pattern was lacunes (n=6/8). Also, we found presence of infarction cores surrounded by hypoperfused areas in rMTT map in acute largearterial territorial infarction.
CONCLUSIONS
Perfusion- and Diffusion- weighted MRIs may be useful in differentiating large-arterial territorial infarction from lacunes.

Keyword

Perfusion MRI; Diffusion MRI; Acute ischemic stroke

MeSH Terms

Blood Volume
Brain
Cerebral Arteries
Cerebral Infarction
Constriction, Pathologic
Diagnosis
Diffusion
Diffusion Magnetic Resonance Imaging
Edema
Hemodynamics
Humans
Infarction
Magnetic Resonance Imaging*
Passive Cutaneous Anaphylaxis
Perfusion
Perfusion Imaging
Stroke*
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