J Korean Knee Soc.  1997 Dec;9(2):229-233.

Osteonecrosis of the Both Knees in a Pediatric Patient following Combination Chemotherapy for Acute Lymphocytic Leukemia: A Preliminary Report

• Suh JT
• Nam TW

Abstract

Osteonecrosis (Avascular necrosis) of the bone is a known complication of systemic corticosteroid therapy and may he dose related. It also has been associated less commonly with nonsteroida1 chemotherapy. Nonetheless, avascular necrosis of bone has heen reported infrequently in children who have received antileukemia regimens including prednisone. We report our experience with one adolescent girl with acute lymphocytic leukernia (ALL) who developed hoth femoral condylar osteonecrosis presenting bone pain after aggressive chemotherapy that including high cumulative dosage of corticosteroid as well as other antileukemia agents. We performed arthroscopic surgery with debridement, multiple drilling and screw fixation to the lesion sites. Eight months after operation, she was free of pain with full range of both knee movements. We got good resuit according to Hughston criteria.

Keyword

Osteonecrosis; Knee

MeSH Terms

Adolescent
Arthroscopy
Child
Debridement
Drug Therapy
Drug Therapy, Combination*
Female
Humans
Knee*
Osteonecrosis*
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Prednisone
Prednisone