J Korean Epilepsy Soc.  2007 Dec;11(2):106-108.

Chronic Recurrent Cholangitis Induced by Carbamazepine

Affiliations
  • 1Department of Neurology, Yonsei University College of Medicine, Seoul, Korea. kheo@yuhs.ac

Abstract

Carbamazepine (CBZ) is one of the most commonly used antiepileptic agents. With its potent effects against seizure or neuropathic pain, it also has several undesirable adverse events. CBZ has been known to induce hepatotoxicity because the drug is mainly metabolized through hepatic system, and asymptomatic liver enzyme elevation occurs in 5~10% of patients receiving CBZ. There are several cases of symptomatic hepatitis or hepatic necrosis by CBZ, however, reports of chronic cholangitis associated with CBZ medication are rare. Here, we present a case of chronic recurrent cholangitis by CBZ with pathological evidence.

Keyword

Carbamazepine; Cholangitis; Adverse event

MeSH Terms

Anticonvulsants
Carbamazepine*
Cholangitis*
Hepatitis
Humans
Liver
Necrosis
Neuralgia
Seizures
Anticonvulsants
Carbamazepine
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